• The North Pan-American highway, that crosses the coast of Ancash longitudinally.
• Three east-west highways that connect the coast with the region of the highlands, most importantly the Callejón de Huaylas:
  • Pativilca - Huallanca
  • Casma - Huaraz
  • Chimbote - Huallanca.
• One highway that crosses the Callejón de Conchucos (Conchucos Alley) longitudinally, to the east of the Cordillera Blanca.

In addition, the region has a network of local roads.