Besides Abancay, the capital and most important economic and political centre, another tourist attraction in the region is Andahuaylas, a rather cold city, located at 2980 meters above sea level (9,800 ft) and the region's agricultural centre. Its main church is the Cathedral de San Pedro, built in Colonial style architecture. A one-piece stone fountain stands out in the Plaza de Armas. Close to Abancay in the way to Cusco is the famed Saywite Stone.

Located 4 km from Andahuaylas, Talavera de la Reyna is another place worth visiting. The main square or Plaza de Armas is remarkable, built in stone with an impressive tower with a clock. Nearby, the thermal baths of Hualalache may be visited. Chalhuanca, the capital of the province of Aymaraes, located at 2,800 m (2,100 ft), preserves beautiful churches built during Colonial times, containing fine wood carvings and gold leaf. A detailed account of Apurimac's architecture can be found in the works of Peruvian Writer and architect Armando Arteaga.

In Antabamba, trepanations so accurately performed that astonish medicine have been found there. Also, mud sculptures, weapons, domestic utensils, and hunting implements.

Considered one of the largest and most beautiful lagoons of Peru, Laguna de Pacucha is located at 3,000 m (9,800 ft) in the route between Andahuaylas and Abancay. It is an ideal place to rest and enjoy nature. Also, fish and duck hunting are allowed.