The coastal strip set the stage for the rise of many pre-Columbian cultures, such as the pre-Ceramic Huaca Prieta civilization, which is more than 5,000 years old & the Cupisnique, which is more than 3,000 years old. From 200 A.C., the first one to expand beyond its cradle was the Moche or Mochica culture. It was basically an agriculture and/or a warrior culture, which built countless temples and palaces such as the Sol (Sun), Luna (Moon), El Brujo & Cao Viejo, and other huacas. The Chimú culture emerged later and built its capital in Chan Chan, the largest pre-Columbian city in South America, & huacas like Esmeralda & Arco Iris (Rainbow). At its zenith, Chan Chan was home to 60,000 inhabitants who stubbornly resisted the expansion of the Inca Empire.

The archaeological remains of Chan Chan, 6 km (3.7 mi) northeast of downtown Trujillo, are rather well-preserved despite being built out of adobe (mud bricks).